Does any PCIe slot support NVMe SSD's automatically or do I need

Does any PCIe slot support NVMe SSD's automatically or do I need pc m 2 slot
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pcie m2 slot : h81 motherboard with nvme slot 2 SATA + NVMe Slot with toggle Switch; SATA Slot; HDMI + VGA - Micro ATX Gaming Desktop PC Motherboard -1

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