2 or 4 RAM slots, does it matter if I only want 16GB RAM?

2 or 4 RAM slots, does it matter if I only want 16GB RAM? 4 slot ram vs 2 slot
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4d slot area What's the performance difference between running 4 sticks of Ram as opposed to 2? No, it's not bad to use all four RAM slots on your motherboard In fact, using all available RAM slots can maximize your computer's memory